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SSR: Balance of the direct and indirect pathways during evidence accumulation

Model: The Indirect Pathway of the Basal Ganglia in Perceptual Decision Making (Wei - Rubin - Wang)
Collator: Youzheng Chen
Created: April 04, 2015
Last modified by: Victor Barres
Last modified: June 30, 2015
Tags: reaction time, caudate, random-dot motion
Brief Description

By incorporating the indirect pathway, it is found that SNr activity can remain unchanged over time during most of the CD ramping process.

Public:  YES
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Figure 1: Behavior of the model Cx-BG-SC circuit when the indirect pathway balances with the direct pathway.
Behavior of the model Cx-BG-SC circuit when the indirect pathway balances with the direct pathway.

"Behavior of the model Cx-BG-SC circuit when the indirect pathway balances with the direct pathway. (A) The two selective populations in the Cx compete with each other and accumulate evidence. (B) CD populations innervated by the Cx show ramping activity. © GPe neurons inhibited by CD neurons decrease their activity. (D) STN neurons increase their activity due to reduced inhibition from the GPe. (E) The innervations from the direct and indirect pathways to the SNr neurons balance with each other, such that SNr activity remains unchanged despite the ramping in the CD (blue and green curves). When the activity of GPe neurons decreases to near zero, a continued increase of CD firing leads to further inhibition of the SNr, whose neural activity exhibits a sharp suppression. (F) The resulting disinhibition of SC neurons, combined with sufficient cortical excitation, eventually triggers a burst response (indicating a categorical choice) in one of the two SC neural populations (with peak activity at ~200 ms as indicated by the black bar). Ramping activity in the cortex is terminated by the feedback signal from the SC, defining a threshold for the decision process."

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